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参考文献
分子层面干预
1. NMN/NR研究
- Yoshino, J., et al. (2016). NAD⁺ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metabolism , 23(6), 1060-1065.
- 重点：NAD+前体通过激活PARP1修复DNA损伤
2. 端粒酶激活剂
- Harley, C.B., et al. (2011). A natural product telomerase activator as part of a health maintenance program. Rejuvenation Research , 14(1), 45-56.
3. 表观遗传重编程
- Ocampo, A., et al. (2016). In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell , 167(7), 1719-1733.
- 重点：OSKM因子诱导细胞年轻化
4. 雷帕霉素与自噬
- Bitto, A., et al. (2014). Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. Science Translational Medicine , 6(268), 268ra179.
细胞层面干预
5. Senolytics药物
- Zhu, Y., et al. (2015). The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Nature Medicine , 21(10), 1164-1174.
- 重点：达沙替尼+槲皮素组合清除衰老细胞
6. FOXO4-DRI肽
- Baar, M.P., et al. (2017). Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell , 169(1), 132-147.
7. CAR-T清除衰老细胞
- Amor, C., et al. (2020). Senolytic CAR T cells reverse senescence-associated pathologies. Nature , 583(7814), 127-132.
8. NAD+与线粒体
- Zhu, X.H., et al. (2020). In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. PNAS , 117(26), 15266-15274.
系统层面干预
9. 年轻血浆异体共生
- Villeda, S.A., et al. (2014). Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine , 20(6), 659-663.
临床试验
10. MSC移植试验
- ClinicalTrials.gov Identifier: [NCT04313647](clinicaltrials.gov)
- 标题：Safety and Efficacy of Mesenchymal Stem Cells in Aging-related Diseases
其他关键研究
- 衰老时钟 ：Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome Biology , 14(10), R115.
- 热量限制 ：de Cabo, R., & Mattson, M.P. (2019). Effects of Intermittent Fasting on Health, Aging, and Disease. NEJM , 381(26), 2541-2551.
