050-Insulin resistance in early-onset colorectal cancer

This paper explores the increasing incidence of early-onset colorectal cancer (EOCRC), highlighting its distinct characteristics compared to late-onset cases. It proposes that insulin resistance (InsR), often linked to lifestyle factors and metabolic imbalances, acts as a primary trigger for EOCRC development in younger individuals. The discussion details how InsR contributes to carcinogenesis through mechanisms like hyperinsulinemia, chronic inflammation, microbiome dysbiosis, and accelerated cellular aging. Finally, the text advocates for earlier detection strategies, lifestyle interventions, and personalized therapeutic approaches to combat this growing public health concern.

References:

• Samuel S M, Varghese E, Büsselberg D. Complexity of insulin resistance in early-onset colorectal cancer[J]. Cancer Cell, 2025, 43(5): 797-802.