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0Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.
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Timestamps:
00:00:00 Start.
00:14:43 Why I'm interested in ketogenic strategies for neurodegenerative prevention.
00:16:18 Mary and Steve Newport's ketone-linked temporary cognitive improvements.
00:18:18 A mechanisms overview for Alzheimer's/dementia.
00:21:25 The immune system as longevity's "fifth horseman" — and why metabolic control is key.
00:22:04 How to measure ketones and GKI.
00:23:00 Fasting vs. ketogenic diet.
00:24:18 There's nothing fishy about sardine fasting.
00:28:32 My hiatal hernia discovery and increased cancer risk concerns.
00:30:04 HSCRP as a superior biomarker to LDL for cardiovascular risk.
00:31:57 Glucose tolerance testing revelations and CGM importance.
00:31:57 Upgrading the metabolic machinery through keto without getting bored.
00:42:07 What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.
00:43:42 Dom's day-to-day diet regimen.
00:45:56 How Dom optimizes his aging dogs with ketones, SARMs, and supplements.
00:51:30 Supplementing for sleep disruption while fasting.
00:55:41 Why Dom doesn't have misgivings about melatonin.
00:59:15 Shingles prevention through fasting protocols.
01:00:15 Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.
01:03:54 Dom at 50-something: Current meal timing and composition.
01:05:57 Blue zone observations: Greek and Sardinian longevity habits.
01:08:16 Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.
01:15:18 Ketone metabolic therapy for cancer.
01:18:15 The metabolic psychiatry revolution.
01:22:10 The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.
01:28:27 Metformin vs. berberine.
01:31:43 The low-dose neuroprotective potential of GLP-1 drugs.
01:34:58 NAD research: MIB-626 and stabilized forms for mitochondrial health.
01:39:48 Idebenone, CoQ10, and the Deanna protocol for ALS.
01:42:05 Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.
01:44:43 KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.
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