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0The paper introduces HippoMaps, an open-access toolbox and online data repository designed for the multiscale mapping and contextualization of the human hippocampus. This platform aggregates diverse datasets, including 3D ex vivo histology, high-field magnetic resonance imaging (MRI) at various resolutions, and in vivo functional data like resting-state functional MRI (rsfMRI) and intracranial electroencephalography (iEEG). HippoMaps utilizes a unified hippocampal unfolding and registration approach to enable direct spatial comparison and analysis of these varied features, moving beyond coarse assessments of the structure. The core aim of the project is to provide a standardized framework for comparing hippocampal features derived from different modalities and scales, aiding in the investigation of structure-function relationships in both healthy individuals and patients with conditions like temporal lobe epilepsy. The researchers note that while structural measures primarily show proximal-distal (subfield) differentiation, functional measures often highlight anterior-posterior organization along the hippocampal long axis.
References:
- DeKraker J, Cabalo D G, Royer J, et al. HippoMaps: Multiscale cartography of human hippocampal organization[J]. Nature Methods, 2025: 1-12.
