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0Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!
This episode is brought to you by:
Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: Qlosi.com
David Protein Bars with 28g of protein, 150 calories, and 0g of sugar: davidprotein.com (Buy 4 cartons, get the 5th free.)
Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $400 off your very own Pod 5 Ultra)
Coyote the card game, which I co-created with Exploding Kittens: coyotegame.com
Timestamps:
- 00:00:00 Start.
- 00:00:52 Why Kevin concluded nearly seven months of sobriety, and the 2-2-2 Rule he now follows for alcohol consumption.
- 00:07:12 My recent adventures in accelerated TMS and bioelectric medicine.
- 00:21:09 The tragic death of Nolan Williams and funding future research through the Saisei Foundation.
- 00:24:23 Aphantasia vs. hyperphantasia, and Joshua Waitzkin's ability to "feel" chess.
- 00:33:12 DORAs for sleep and Alzheimer's prevention: Matt Walker, Belsomra, and the terrifying p-tau blood test.
- 00:41:21 Dale Bredesen's kitchen-sink approach to dementia and the ketogenic connection.
- 00:46:22 The rapid pace of AI development: Why your opinion from three months ago is already obsolete.
- 00:49:40 Google's full-stack advantage: TPUs, Gemini 3, and why they were built for this moment.
- 00:52:50 The future of venture capital: Seed rounds shift later as entrepreneurs gain leverage.
- 00:58:05 Kevin's three AI investment buckets: Power, data centers, and bloated companies ripe for automation.
- 01:02:05 Holiday gift ideas and recommended reading.
- 01:17:41 The Way App and meditation with Zen master Henry Shukman.
- 01:21:44 Kevin's AI stack: Nothing earbuds, Sandbar ring, Notion AI, and the NotebookLM podcast hack.
- 01:26:58 Oboe.fyi: The AI learning platform and my investment philosophy.
- 01:32:09 My new girlfriend, the perils of modern dating apps, and building a communication toolkit.
- 01:38:17 Terry Real's relationship wisdom: Why objective reality has no place in an argument.
- 01:47:18 Dog updates: Molly, a new puppy, and Toaster on rapamycin.
- 01:47:58 Parting thoughts and happy holidays.
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