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0Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.
This episode is brought to you by:
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- Coyote the card game, which I co-created with Exploding Kittens: coyotegame.com
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Timestamps:
- 00:00:00 Who is Dominic D'Agostino?
- 00:04:37 Ketosis benefits: Quieting the mind, GABA elevation, metabolic psychiatry.
- 00:09:24 My Lyme disease story: Pseudo-dementia reversed in 3-4 days of ketosis.
- 00:13:50 Spirochetes are glycolytic: Starve the bug, boost the immune response.
- 00:19:20 Ketosis and cancer: Slowing glycolytic tumors, enhancing standard care.
- 00:20:50 My 18-day keto experiment: Mood stabilization, Alzheimer’s prevention hopes.
- 00:23:19 Metabolic memory: Carryover effects and Valter Longo’s fasting mimicking research.
- 00:27:11 Intermittent fasting as keto on-ramp: My 2-8 p.m. eating window.
- 00:29:15 Dom’s budget keto meal: Canned mackerel, MCT oil, apple cider vinegar.
- 00:33:28 My ketone measurement paradox: Feeling sharp at 0.2 mM readings.
- 00:36:56 The carburetor analogy: Ketone production vs. utilization explained.
- 00:38:43 Breath ketones vs. blood ketones: Better indicator in caloric deficit.
- 00:39:47 Gluconeogenesis fears: Fat, fiber, and salt to slow protein absorption.
- 00:45:25 The bunless double cheeseburger question: 80 grams of protein in one sitting.
- 00:49:03 Post-meal walking and GLUT4 activation: Timing your glucose disposal.
- 00:51:02 CGM and ketone monitor limitations: When your devices gaslight you.
- 00:58:05 Rabbit starvation and protein-veggie days: Why your body won’t bankroll its own ketosis.
- 01:05:44 Alzheimer’s prevention: Biomarkers, B12, hsCRP, and metabolic health.
- 01:09:40 My family history: Letrozole, metabolic dysfunction, and rapid cognitive decline.
- 01:13:17 Minimum effective dose: 80% of benefits from low-carb Mediterranean.
- 01:18:56 One week per month protocol: Aggressive calorie cut to ramp ketones.
- 01:23:12 GKI sweet spot: Target 1-4, aim for 1-2 during intensive weeks.
- 01:36:22 Exogenous ketones 101: Palatability, tolerability, pharmacokinetics, toxicity.
- 01:39:21 1,3-Butanediol warnings: Liver toxicity, NAD depletion, dependency risk.
- 01:54:22 Intermittent fasting vs. ketogenic breakfast.
- 01:59:09 My accidental intoxication story.
- 02:03:23 Dr. Veech tribute: Student of Hans Krebs, ketone ester pioneer.
- 02:05:08 Fiber on keto: Wild blueberries, broccoli, apples, walnuts.
- 02:09:58 The tainted gummies incident: Dom’s forensic investigation underway.
- 02:13:08 Thanks to Dr. Boz and Medifoodz.
- 02:16:19 Parting thoughts.
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