This review explores the human skin microbiome, detailing how a complex ecosystem of bacteria, fungi, and viruses maintains dermatological health and immune function. Advances in metagenomic sequencing have allowed researchers to identify specific microbial shifts associated with conditions like atopic dermatitis, acne, and psoriasis. By understanding these interspecies interactions, scientists are developing novel microbiome-based therapeutics, including probiotics, phage therapy, and engineered bacteria. While these treatments offer targeted precision for skin repair and inflammation, they face hurdles such as individual variability and colonization resistance. Ultimately, the source highlights the transition from mapping microbial diversity to leveraging it for innovative medical solutions.

References:

• Oh, J., Voigt, A.Y. The human skin microbiome: from metagenomes to therapeutics. Nat Rev Microbiol 23, 771–787 (2025). doi.org