Hematopoietic stem cell (HSC) fitness declines as divisions accrue, shifting BCAA usage from catabolic to anabolic activity. This metabolic drift accelerates the cell cycle and causes lineage infidelity. Supplementing with the metabolite aKIC restores balanced output and regeneration.

References:

• Bartram J, Treichel S, Song B A, et al. Activation of a branched-chain amino acid rheostat restores replication-dependent hematopoietic stem cell fitness[J]. Cell Stem Cell, 2026.