Luna et al. found that Myrf is essential for mesothelium function and lung development. Deleting Myrf causes lung hypoplasia and congenital diaphragmatic hernia (CDH). Without Myrf and Yap/Taz, mesothelial cells transform into ectopic smooth muscle, mimicking adult PPFE.

References:

• Luna G, Verheyden J M, Tan C, et al. MYRF controls mesothelium specification, signaling, and plasticity in lung development[J]. Developmental Cell, 2026.