Researchers introduced scRank, a computational tool using single-cell transcriptomics and gene regulatory networks to identify drug-targeted cell types. They identified Ex_9 neurons as targets for SSRIs in MDD and found that Tanshinone IIA binds CTSB in macrophages.

References:

• scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory networkLi, Chengyu et al.Cell Reports Medicine, Volume 5, Issue 6, 101568