High-resolution spatial transcriptomics reveals that JAG1-NOTCH1 signaling drives the formation of a CAF-Epi niche during esophageal cancer progression. This niche triggers ECM remodeling and creates an immune-suppressive barrier, facilitating tumor evasion and poor prognosis.

References:

• Chang J, Lu J, Liu Q, et al. Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis[J]. Cancer Cell, 2025, 43(3): 380-397. e7.