Research identifies low-gamma power in the anteromedial orbitofrontal cortex (amOFC) as a biomarker for OCD distress. Stimulating the ventral basal ganglia (NAc-VeP) reduces this neural activity and alleviates symptoms, supporting personalized, closed-loop deep brain stimulation.

References:

• Nho Y H, Qiu L, Seilheimer R L, et al. Human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics[J]. Cell, 2026.