This review examines the development of the cancer stem cell (CSC) model specifically within medulloblastoma, the most prevalent malignant pediatric brain tumor. It tracks the shift from early cell-sorting techniques and surface markers like CD133 to modern single-cell RNA sequencing, which reveals a complex landscape of cellular plasticity. The text details how different medulloblastoma subgroups originate from specific developmental lineages in the brain, such as the rhombic lip or granule neuron progenitors. By identifying these tumor-propagating cells, researchers hope to discover targeted therapies that can overcome drug resistance and recurrence. Ultimately, the source emphasizes integrating genomics with functional stem cell biology to improve patient survival and long-term quality of life.

References:

• Werbowetski‐Ogilvie T E. From sorting to sequencing in the molecular era: the evolution of the cancer stem cell model in medulloblastoma[J]. The FEBS Journal, 2022, 289(7): 1765-1778.