This article explores the integration of untargeted mass spectrometry (MS) and wearable biosensors to advance noninvasive health monitoring. While MS serves as a powerful discovery engine for identifying complex biomolecular patterns in fluids like sweat and saliva, wearable devices provide the continuous, real-time data necessary for tracking dynamic physiological changes. The authors establish specific criteria for translating laboratory-discovered biomarkers into on-body applications, emphasizing the need for molecular stability and high sensitivity. By bridging these two technologies, the researchers propose a move away from episodic clinical testing toward a personalized, longitudinal monitoring framework. This synergistic approach aims to transform how we detect and manage conditions ranging from metabolic stress to chronic disease in real-world settings.

References:

• Kim M J, Lasalde-Ramírez J A, Heng W, et al. Biomolecular profiling for noninvasive health monitoring[J]. Nature Biotechnology, 2026: 1-14.