1
0Title:
Development of nucleic acid-based gene regulators for metabolic engineering
and molecular diagnosis
Astract:
Synthetic biology aims at providing solutions for the challenges of modern society and paving new ways to understand life. Realizing the true potential of synthetic biology is dependent on the ability to regulate gene expression. Nucleic acids offer new opportunities for developing artificial gene regulators based on their programmability, versatility, low genetic footprint, and economic production both in vivo or in vitro. In this talk, the speaker will introduce examples of artificial gene regulators developed through rational design and artificial evolution. Specifically, an efficient development process for RNA-based inducible gene regulators and their application to sensing of small molecules will be presented. Additionally, a rationally-designed nucleic acid-based molecular program for rapid diagnosis of pathogens called SENSR will be discussed.
Personal Profile:
Dr. Sungho Jang currently serves as an Associate Professor in the Division of Bioengineering at Incheon National University, South Korea. His research is centered on redesigning biological systems by integrating principles from synthetic biology and artificial evolution. A core focus of his approach is the development and application of nucleic acid-based tools, particularly synthetic RNA devices like riboswitches, to serve as artificial gene regulators and metabolite sensors. This expertise is applied to develop advanced platforms for the production of valuable chemicals and pharmaceuticals, the manipulation of the microbiome for therapeutic purposes, and the creation of novel tools for the molecular diagnosis of diseases.
