This research introduces a pioneering spatiotranscriptomics platform designed to map the entire molecular and cellular landscape of the laboratory mouse. By combining Array-seq technology with a novel computational algorithm called LABEL, researchers can now simultaneously identify 379 distinct cell types and 16 major organ systems within a single whole-body section. This framework transitions biological study from isolated tissue analysis to a comprehensive systems biology approach, capturing how cells interact across the entire organism. To demonstrate its utility, the authors mapped systemic inflammation in a model of endotoxemia, uncovering widespread transcriptional shifts and gene regulatory networks driven by STAT1 and IRF1. Ultimately, this resource provides a scalable, high-resolution toolkit for investigating genetics, disease progression, and pharmacology at a whole-body scale.

References:

• Clevenger M H, Cipurko D, Patil A, et al. Whole-body molecular and cellular mapping of the laboratory mouse[J]. Cell, 2026.