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0This study presents a comprehensive atlas of the human amnion during the first trimester of pregnancy using single-cell transcriptomics. Researchers identified six primary cell types across the epithelial, mesenchymal, and macrophage lineages, uncovering how these populations interact through pathways like BMP4 and TGF-β to drive tissue growth. The data highlights significant cellular remodeling, including transitions where cells shift from epithelial states into mesenchymal or immune roles. Furthermore, the authors compared in vivo human data with non-human primates and stem cell-derived models to evaluate how accurately laboratory systems mimic natural development. This research provides a vital resource for understanding the regenerative potential and immunosuppressive properties of the amnion. Such insights are essential for advancing cell-based therapies and improving our knowledge of how this membrane protects and supports the growing embryo.
References:
Hu W, Sancho-Serra C, Gantner C W, et al. Atlas of amnion development during the first trimester of human pregnancy[J]. Nature cell biology, 2025, 27(7): 1175-1185.
