985-Organellar Insights in Ageing and Longevity

These sources examine the critical role of cellular organelles in controlling ageing and lifespan. Researchers highlight how lysosomes, mitochondria, and the endoplasmic reticulum function as metabolic signalling hubs that maintain cellular balance. The text details how these structures communicate through dynamic crosstalk and inter-tissue signalling to influence organismal fitness. Beyond internal processes, the research explores how organelle interactions regulate microbiome-host relations and the transgenerational inheritance of longevity. Finally, the authors evaluate how longevity-promoting interventions, such as dietary restriction and pharmacological treatments, specifically target organelle health to delay age-related decline.

References:

• Mannino P, Park M, Wang M C. Organellar insights in ageing and longevity[J]. Nature Cell Biology, 2026: 1-14.