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0The paper details the development of the mCAS (multicentric Chinese aging standardized cohort), a comprehensive scientific initiative designed to quantify human biological age. Researchers established a multidimensional framework by integrating clinical, physiological, and multi-omics data from over 2,000 individuals across diverse regions of China. This architecture includes specialized aging clocks, such as the core capacity clock (CC-clock) for physical decline and the multimodal clock (MM-clock) for high-precision molecular tracking. A key discovery identifies the accumulation of liver-derived coagulation factors as a primary mechanistic driver of both vascular and systemic aging. Ultimately, the study provides a foundational standardized system for identifying biomarkers, predicting healthspan, and developing future interventions against age-related deterioration.
References:
Li J, Jiang B, Zhang W, et al. Multimodal clocks of human aging[J]. Cell, 2026.
