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0This study presents a comparative transcriptomic atlas that evaluates how well mouse models of demyelination mimic the cellular landscape of human multiple sclerosis (MS). By integrating single-cell and single-nucleus RNA sequencing datasets, researchers discovered that the cuprizone (CPZ) model uniquely produces a stressed oligodendrocyte state While both the CPZ and lysophosphatidylcholine (LPC) models converge on a shared immune-responsive state that closely mirrors the transcriptional dysfunction found in human Multiple Sclerosis lesions. during the repair phase, they only partially capture the diversity of progenitor and microglial cells seen in patients. The findings reveal that while mouse models exhibit a conserved core of microglial activation, they lack the full range of cellular heterogeneity present in the chronic stages of human disease. Ultimately, this research provides a harmonized framework to help scientists strategically select the most appropriate animal models for studying myelin injury and testing new neuroregenerative therapies.
References:
Aboelnour E L, Vanoverbeke V R, Maupin E A, et al. A comparative transcriptomic analysis of mouse demyelination models and Multiple Sclerosis lesions[J]. Nature Communications, 2026, 17(1): 3858.
