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0This research explores the immune landscape of high-grade serous ovarian cancer (HGSOC) by analyzing patient-derived tumors and their draining lymph nodes (TDLNs). The study reveals that while B cells in tumors are linked to better outcomes, the TDLNs actually lack active germinal centers and are instead dominated by quiescent memory B cells. These memory cells are clonally related to B cells within the tumor and produce antibodies that specifically target ovarian cancer cells. The authors identify a high density of DC-SIGN+ macrophages in the lymph nodes, which appear to suppress the immune response by engulfing activated B cells. Ultimately, the findings suggest that TDLNs function as quiescent reservoirs for tumor-reactive cells that support ongoing immunity within the tumor mass.
References:
Nathan N, Paparoditis P, Sarusi-Portuguez A, et al. Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells[J]. Immunity, 2026.
