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0The paper introduces GEMINI, a sophisticated protein-based recording platform designed to track the chronological history of cells within living tissues. Unlike traditional methods that provide only static snapshots, this technology utilizes computational protein design to create 3D assemblies that grow predictably, much like the concentric rings of a tree. These structures capture and store biochemical signals and transcriptional activities as fluorescent patterns, which researchers can later decode to determine the exact timing and magnitude of cellular events. The system demonstrates high biocompatibility, functioning effectively in both cell cultures and live animal models without disrupting essential biological processes like cell division or neuronal firing. By providing a retrospective narrative of physiological and pathological dynamics, GEMINI offers a robust tool for mapping complex interactions in fields such as immunology and neuroscience.
References:
Yan Y, Lu J, Li Z, et al. Genetically encoded assembly recorder temporally resolves cellular history[J]. Nature, 2026, 652(8111): 1049-1059.
