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0This article identifies a specific subset of blood-forming stem cells, known as Meg3+ HSCs, that significantly increases during the aging process. The researchers discovered that inflammatory signals trigger a chemical change called H3K23ac, which causes these stem cells to favor the production of myeloid and platelet cells over vital immune cells. By using multi-omics profiling, the study demonstrates how the protein TRIM24 interacts with this chemical mark to disrupt the natural balance of blood production. Crucially, the authors found that interfering with this specific epigenetic interaction can restore youthful cell output and reduce markers of cellular aging. These findings offer a new understanding of immune decline and highlight potential therapeutic targets for revitalizing the immune systems of the elderly.
References:
Wei N, Zhan H, Deng Y, et al. Epigenetic programming by H3K23ac defines lineage fate of Meg3+ haematopoietic stem cells and drives immune ageing[J]. Nature Cell Biology, 2026: 1-20.
