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0This study utilizes longitudinal single-cell RNA and TCR sequencing to examine how immune cells transform during frontline chemoimmunotherapy for advanced gastric cancer. By analyzing serial biopsies, researchers identified that patients with prolonged survival maintain a high abundance of progenitor-exhausted T cells that exhibit stem-like qualities and tumor reactivity. These favorable outcomes are further supported by the recruitment of B cells, which interact with T cells to promote their persistence and anti-tumor activity. Additionally, the data suggests that effective immune responses rely on circulating T cell clones that infiltrate the tumor following treatment. Ultimately, the findings highlight a coordinated immune ecosystem where early chemotherapy-induced remodeling and B-cell-mediated costimulation are essential for achieving durable clinical benefits.
References:
Wright S J, Kang S, An M, et al. Differential T cell clonal dynamics underlie outcomes to frontline chemoimmunotherapy in advanced gastric cancer[J]. Cell Reports Medicine, 2025.
