1338-Ductal Dysfunction and CFTR Responses in Pancreatitis

This research article from Cell Stem Cell details the creation of a patient-derived organoid (PDO) biobank to study chronic pancreatitis. By utilizing samples from individuals with various disease triggers, scientists identified three distinct molecular subtypes that exist regardless of the initial cause of the condition. A significant portion of the study focuses on how CFTR mutations and variants lead to ductal dysfunction within these lab-grown tissues. Crucially, the authors demonstrate that CFTR-modulator drugs can successfully restore cellular transport and reduce inflammatory signaling. These findings suggest that organoid models serve as a powerful tool for developing personalized therapies for patients suffering from long-term pancreatic inflammation.

References:

• Osorio-Vasquez V, Zhu J, Lumibao J C, et al. Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis[J]. Cell Stem Cell, 2026.