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0This research article examines the use of patient-derived organoids (PDOs) to study the cellular mechanics of chronic pancreatitis (CP). By establishing a biobank of 37 organoid models, researchers identified three molecular subtypes of the disease that exist regardless of the original cause of inflammation. The study highlights how these models retain the intrinsic inflammatory traits found in human patients, specifically focusing on ductal dysfunction. A significant finding involves the use of CFTR modulators to repair impaired transport pathways in organoids with genetic mutations. Successfully restoring this function led to a notable reduction in inflammatory and mitogenic signaling, suggesting new therapeutic avenues for the condition. The work utilizes multi-omic profiling and functional assays to provide a comprehensive look at how these lab-grown tissues can predict drug responses in a clinical context.
References:
Osorio-Vasquez V, Zhu J, Lumibao J C, et al. Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis[J]. Cell Stem Cell, 2026.
