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45“能力越大，责任越大”——这句经典的台词塑造了我们熟知的蜘蛛侠，但你是否好奇过，从生命科学的角度来看，成为蜘蛛侠到底有多难？ 今天这期《生物漫游指南》中，我们一起用硬核的生物学与物理学原理，为你深度解构蜘蛛侠的超能力：被转基因或放射性蜘蛛咬一口，真的能把蜘蛛的DNA转移到人体内发生基因变异吗？为什么蜘蛛侠在摩天大楼之间靠蛛丝做钟摆运动时，肩膀承受着惊人的拉力却没有脱臼脱离？蜘蛛侠又为什么可以在大楼上飞檐走壁呢？如果蜘蛛侠能自由地释放蛛丝，他身上得带着多少蛛丝呢？我们一起用生命科学角度一起聊聊蜘蛛侠里的生物吧～
加听友群请加小导游：bio_kiwi
本期节目，我们将在8月6日抽取评论区的听友，送上当地电影院《蜘蛛侠：崭新之日》电影票一张！
时间点：
三代真人蜘蛛侠大盘点：谁的超能力设定最符合“生物学”？
被放射性蜘蛛咬伤，真的会让人获得超能力吗？
现实生活中被剧毒蜘蛛咬伤，你的身体到底会发生什么？
真实的“基因篡改”大师：寄生蜂与病毒如何改变宿主基因
蜘蛛的超级力量解析：“平方立方率”与奥特曼身型悖论
蜘蛛惊人弹跳力的真正秘诀：独特的体液加压系统
钟摆运动的物理计算：蛛丝摆荡为什么会对肩关节极其不友好？
飞檐走壁的微观奥秘：成千上万根细毛与“范德华力”
表面积与体重的博弈：人类想靠粘附力爬墙，需要把全身40%变成防滑垫？
蜘蛛感应的科学真相：极度灵敏的听觉神经（听毛）与裂缝感受器
蜘蛛的超强视觉与人类大脑应对危险的本能防御机制
蛛丝的力学奇迹：媲美钢材的强度、韧性与从液态到固态的奇妙转换
沉重的生物代价：大量吐丝会导致身体被掏空？一天需要吃几百个鸡蛋！
现实世界的科技版蜘蛛侠指南：微流控、外骨骼和体外设备
本期提及图片：
《Amazing Fantasy》第 15 期中的放射性蜘蛛咬伤画面：
2002 年电影中的咬伤画面：
《Amazing Fantasy》第 15 期中蜘蛛侠释放蛛丝的装置：
蜘蛛不同蛛丝的分类与功能：
本期设计的BGM：
漫威系列电影片头
蜘蛛侠系列电影片段
电影《蜘蛛侠：平行宇宙》情感主题曲 - Let Go
本期参考文献：
[1] Marvel, “Spider-Man: Brand New Day” 官方影片页与预告；Sony 中国，2026 年 7 月 29 日中国内地上映信息。www.marvel.com；www.sony.com.cn
[2] Marvel 官方银幕人物资料：Peter Parker／Spider-Man。www.marvel.com
[3] Marvel, Amazing Fantasy (1962) 系列页；Spider-Man 漫画人物资料。www.marvel.com；www.marvel.com
[4] American Humane, Spider-Man (2002) 拍摄动物记录。www.americanhumane.org
[5] World Health Organization. Public-health significance of urban pests／International Medical Guide for Ships：蜘蛛咬伤相关章节。iris.who.int
[6] Lüddecke T, et al. Spider Venom: Components, Modes of Action, and Novel Strategies in Transcriptomic and Proteomic Analyses. Toxins. 2019;11:611. pmc.ncbi.nlm.nih.gov
[7] Zelezetsky I, et al. A Review on Genotoxic and Genoprotective Effects of Biologically Active Compounds of Animal Origin. Toxins. 2023. pmc.ncbi.nlm.nih.gov
[8] Bracovirus—寄生蜂—鳞翅目宿主整合与免疫抑制研究。pmc.ncbi.nlm.nih.gov；www.nature.com
[9] Wang D, et al. Viral vector platforms within the gene therapy landscape. Signal Transduction and Targeted Therapy. 2021. www.nature.com；AAV persistence review：pmc.ncbi.nlm.nih.gov
[10] Burd M, et al. Large ants do not carry their fair share: maximal load-carrying performance of leaf-cutter ants. Journal of Experimental Biology. 2019. pubmed.ncbi.nlm.nih.gov
[11] Keller RA, et al. The loss of flight in ant workers enabled an evolutionary redesign of the thorax for ground labour. Frontiers in Zoology. 2020. pubmed.ncbi.nlm.nih.gov
[12] Weihmann T, et al. Hydraulic leg extension is not necessarily the main drive in large spiders. Journal of Experimental Biology. 2012. journals.biologists.com
[13] Brandt EE, et al. Jump takeoff in a small jumping spider. Journal of Comparative Physiology A. 2021. pubmed.ncbi.nlm.nih.gov；Nabawy MRA, et al. Energy and time optimal trajectories in exploratory jumps. Scientific Reports. 2018. pmc.ncbi.nlm.nih.gov
[14] Kesel AB, et al. Getting a grip on spider attachment: an AFM approach to microstructure adhesion in arthropods. Smart Materials and Structures. 2004. 资料摘要：physicsworld.com
[15] Labonte D, et al. Extreme positive allometry of animal adhesive pads and the size limits of adhesion-based climbing. PNAS. 2016. pmc.ncbi.nlm.nih.gov
[16] Barth FG. Spider senses—technical perfection and biology. Zoology. 2002. pubmed.ncbi.nlm.nih.gov；Bathellier B, et al. Dynamics of spider trichobothria to natural stimuli. pmc.ncbi.nlm.nih.gov
[17] Barth FG. A spider in motion: facets of sensory guidance. Journal of Comparative Physiology A. 2021. pmc.ncbi.nlm.nih.gov
[18] Zurek DB, Nelson XJ. Saccadic tracking of targets mediated by the anterior-lateral eyes of jumping spiders. 2012. pubmed.ncbi.nlm.nih.gov
[19] De Agrò M, et al. Eye-specific detection and a multi-eye integration model of biological motion perception. Journal of Experimental Biology. 2024. pubmed.ncbi.nlm.nih.gov
[20] Cushing CA, et al. Human superior colliculus pathways represent the form and motion of looming objects. 2026. pmc.ncbi.nlm.nih.gov；Visual looming is a primitive for human emotion. pmc.ncbi.nlm.nih.gov
[21] Gosline JM, et al. The mechanical design of spider silks: from fibroin sequence to mechanical function. Journal of Experimental Biology. 1999. journals.biologists.com
[22] Finnigan W, et al. The effect of terminal globular domains on recombinant mini-spidroins. Scientific Reports. 2020. www.nature.com
[23] Rising A, Johansson J. Toward spinning artificial spider silk. Nature Chemical Biology. 2015. www.nature.com；Andersson M, et al. Biomimetic spinning of artificial spider silk from a chimeric minispidroin. 2017. www.nature.com
[24] Agnarsson I, et al. Extraordinary silk from Darwin’s bark spider. PLOS ONE. 2010. journals.plos.org
[25] Victoria and Albert Museum. The story of the golden spider silk cape. www.vam.ac.uk
[26] Nature profile: Randolph Lewis and recombinant spider silk. www.nature.com
[27] Vollrath F, Knight DP. Liquid crystalline spinning of spider silk. Nature. 2001. www.nature.com
[28] Whittall DR, et al. Host Systems for the Production of Recombinant Spider Silk. Trends in Biotechnology. 2021. pubmed.ncbi.nlm.nih.gov
[29] Production and secretion of recombinant spider silk in Bacillus megaterium. Microbial Cell Factories. 2024. link.springer.com
[30] AMSilk 官方技术与产品信息，访问于 2026-07-29。www.amsilk.com
[31] Spiber 官方新闻与 Brewed Protein™ 材料信息，访问于 2026-07-29。spiber.inc
[32] Seevix 官方技术信息，访问于 2026-07-29。www.seevix.com
[33] Kraig Biocraft Laboratories 2026 年产能计划，公司前瞻性公告。www.kraiglabs.com
[34] Spintex 官方技术信息，访问于 2026-07-29。www.spintex.co.uk
[35] Bolt Projects Holdings SEC 申报文件：2023 年停止 Microsilk 开发。www.sec.gov
[36] BEAL Zenith 9.5 mm 动力绳技术参数。uk.beal-planet.com
[37] National Academies / NCBI Bookshelf，Reference Man 体成分表。www.ncbi.nlm.nih.gov
[38] Jäger R, et al. International Society of Sports Nutrition Position Stand: protein and exercise. Journal of the ISSN. 2017. pubmed.ncbi.nlm.nih.gov
