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0This review article explores neddylation, a vital protein modification process that significantly influences cancer development and progression. The authors detail how this enzymatic cascade regulates protein stability, localization, and function, thereby sustaining various cancer hallmarks such as immune evasion, metabolic rewiring, and therapeutic resistance. While typically viewed as oncogenic, the text highlights that neddylation can have dual effects depending on the specific tumor environment and cellular stress factors like hypoxia. By examining the molecular mechanisms and pathological features of this process, the research identifies targeting the NEDD8 pathway as a promising frontier for innovative clinical treatments. Through a comprehensive analysis of various malignancies, the source provides a foundational rationale for using neddylation inhibitors to overcome treatment obstacles and improve patient outcomes.
References:
Deng N, Sun Q, Yu X, et al. Decoding neddylation in malignancies: molecular mechanisms, biological functions, therapeutic resistance, and clinical potential[J]. Cell Death & Disease, 2026, 17(1): 37.
