6
0This review article examines pyroptosis, a form of inflammatory programmed cell death, through the lens of subcellular organelle dynamics and their role in cancer therapy. Beyond traditional molecular pathways, the text highlights how the nucleus, mitochondria, lysosomes, and Golgi apparatus form an integrated network that executes cell death via gasdermin (GSDM) pore formation. The authors synthesize recent advances in organelle-targeted induction strategies, demonstrating how inter-organelle crosstalk can bypass tumor resistance and enhance anti-tumor immunity. By analyzing structural disruptions like mitochondrial bursting and cytoskeletal collapse, the research advocates for a spatiotemporal paradigm in oncology. Ultimately, the sources suggest that quantifying organelle damage can provide precise biomarkers for optimizing immunotherapy and overcoming therapeutic bottlenecks.
References:
Qiu A P, Lin J D, Hu H R, et al. Organelles and cancer cell pyroptosis: overview and perspectives[J]. Cell Death & Disease, 2025, 17(1): 142.
