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0This review explores the critical role of membrane contact sites (MCSs), which are dynamic regions where cellular organelles interact to regulate essential functions like calcium signaling, lipid metabolism, and energy homeostasis. Historically viewed as independent structures, organelles are now recognized as part of a sophisticated communication network facilitated by specialized tethering proteins. The text highlights how disruptions in these interactions are closely linked to cancer progression, influencing tumor growth, metabolic reprogramming, and resistance to therapy. By examining specific hubs such as ER-mitochondria and mitochondria-lysosome contacts, the authors identify potential oncological targets for future treatments. Ultimately, modulating these inter-organelle bridges may offer a novel therapeutic strategy to combat malignant cell survival and metastasis.
References:
Celotti I, Scavezzon M, Toffanin S, et al. Organelle contact sites in cancer cells[J]. Cell Death & Disease, 2026.
