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0This review article examines the CAF–TAM axis, a critical cellular partnership between cancer-associated fibroblasts and tumor-associated macrophages that drives malignancy. By integrating single-cell and spatial multi-omics, the authors illustrate how these cells coordinate extracellular matrix remodeling, metabolic adaptation, and immune evasion. The text details various specialized subpopulations, such as contractile myCAFs and immunosuppressive SPP1⁺ TAMs, which cluster together to form barriers against therapy. Beyond mere description, the source explores how epigenetic shifts and metabolic coupling maintain these protumor environments. Ultimately, the research provides a blueprint for novel therapeutic strategies aimed at disrupting this crosstalk to improve patient outcomes.
References:
Fu Y, Li M, Wu S, et al. Decoding the CAF–TAM axis: multi-omics dissection and therapeutic targeting of stromal–immune crosstalk in the tumor microenvironment[J]. Cell Death & Disease, 2026.
