0
0This research paper utilizes single-cell RNA sequencing and spatial transcriptomics to map the progression of cervical cancer from healthy tissue to malignant tumors within the same patients. The study identifies a distinct spatiotemporal architecture characterized by a shift toward an immunosuppressive microenvironment, marked by changes in fibroblast, endothelial, and B-cell subpopulations. Researchers highlight a specific gene signature—CLDN1, ISG15, and PTGDS—as vital biomarkers for early diagnosis and therapeutic intervention. Mechanistically, ISG15 is shown to stabilize FGF1, thereby activating the PI3K/AKT/mTOR signaling pathway to drive cancer growth. The authors conclude that targeting this pathway with FGFR1 inhibitors offers a promising strategy for improving outcomes in cervical squamous cell carcinoma. These findings provide a comprehensive atlas of the cellular and molecular changes occurring during the precancer-to-cancer transition.
References:
Zhou Y, Luo Y, Ge Y, et al. Integrated multi-omics profiling of treatment-naive cervix uteri premalignant lesions and cervical squamous cell carcinoma reveals ecosystem and drivers underlying cervical cancer progression[J]. Cell Death & Disease, 2026.
