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0The paper describes the creation of an integrated theranostic nanoplatform designed to advance precision cancer care by combining diagnosis and treatment into a single system. Researchers developed nanoparticles labeled with the radionuclide 68Ga and a near-infrared fluorophore, which allow for rapid PET/CT imaging and real-time fluorescence-guided surgery. Beyond mapping tumors, the platform utilizes AIE-active photosensitizers to deliver photodynamic and photothermal therapies, effectively killing residual cancer cells through localized heat and reactive oxygen species. Testing in mouse models demonstrated that this multifunctional approach can accurately identify primary and metastatic lesions while successfully preventing tumor recurrence. Overall, the study highlights a "diagnosis-to-treatment" system with significant potential for clinical translation in managing complex malignancies.
References:
Zhang G L, Hou D Y, Chen Y, et al. Integrated theranostic nanoplatform empowers precision cancer care via radionuclide-labeled NIR-II aggregation-induced emission luminogens[J]. Nature Communications, 2026.
