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0This research introduces CeO2-NMUiECs, a sophisticated dual-targeting nanotherapeutic designed to treat ischemic diseases by repairing damaged blood vessels. Scientists engineered these nanovesicles from iPSC-derived endothelial cells and armed them with antioxidant ceria nanozymes to survive the toxic, oxygen-depleted environments of injured tissues. The platform leverages a natural homing mechanism to navigate directly to sites of injury, where it simultaneously neutralizes harmful reactive oxygen species and delivers pro-angiogenic proteins to stimulate vessel growth. Rigorous testing across diverse models—including stroke, heart attack, and bone necrosis—demonstrated that the treatment significantly restores organ function and promotes tissue regeneration. By merging biological signaling with catalytic chemistry, this universal strategy transforms passive drug carriers into active agents capable of rescuing the ischemic endothelium.
References:
Jiang H, Wang Y, Huang H, et al. Universal catalytic endothelial lineage nanovesicles for targeting and rescuing ischemic endothelium[J]. Cell Reports Medicine, 2026, 7(8).
