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0This paper investigate the neocortical mechanisms that regulate sleep and arousal, specifically focusing on a sparse population of somatostatin and chondrolectin-expressing (Sst-Chodl) inhibitory neurons. Utilizing intersectional genetics and two-photon calcium imaging, researchers demonstrate that these long-range projecting neurons are preferentially active during low-arousal states such as slow-wave sleep and quiet wakefulness. Furthermore, experimental optogenetic activation of Sst-Chodl cells reveals that they actively promote widespread cortical synchronization and sleep-related behaviors. Ultimately, the findings highlight a crucial role for intracortical circuits in sleep regulation, complementing traditional subcortical mechanisms.
References:
Ratliff J M, Terral G, Vazquez A, et al. Neocortical long-range inhibition promotes cortical synchrony and sleep[J]. Nature, 2026: 1-12.
