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0The paper investigate how interferon-α (IFNα) transforms blood cell development and clonal dynamics in patients with myeloproliferative neoplasms. By utilizing single-cell multiomics, researchers demonstrate that IFNα treatment simultaneously drives opposing immune pathways, activating anti-inflammatory responses while spawning an accelerated inflammatory myeloid progenitor state. Furthermore, the treatment reshapes chromatin accessibility and enhances PU.1 transcription factor activity, ultimately expanding lymphoid progenitors and reversing abnormal myeloid bias.
References:
Lama C, Isakov D, Rosenberg S, et al. Type 1 interferon perturbates clonal competition by reshaping human blood development[J]. Nature Genetics, 2026: 1-15.
