Full episode with 20 minutes of new material at the end. Software factories, vertical integration, the regulatory frontier, and the autonomous company. Part 1: Waste Tokens, Save Time 00:00 Three Frontier Founders 01:27 AI Software Factories 04:15 Waste Tokens, Save Time 05:47 Models Instructing Humans 09:29 Is Pure Software Dead? 12:03 You Don't Get Stuck Anymore Part 2: Vibe Coding Hardware 14:39 Vibe Coding a Turbine Blade 18:07 Open Source Compounds China's Advantage 20:15 You Always Want the Smartest Model 22:44 Software Still Needs Hands 24:43 Humans Are Becoming Verifiers Part 3: The Regulatory Frontier 27:53 The Regulatory Red Queen Race 32:32 Why There's No Innovation in Healthcare 36:49 We Need a True 50-State Experiment 40:31 China's FDA Is Beating Ours 43:37 Healthcare Is a Communist Society Inside Capitalism 45:57 Sid's Story: N-of-1 Medicine Part 4: The Autonomous Company 47:49 Autonomous Infrastructure 51:25 Your Job Is to Train the Agent 54:54 The Next Lord of the Rings 59:08 What's Your Definition of Art? 1:05:00 Can AI Have New Ideas? 1:07:03 A Very Large Number of Small Teams With Guillermo Rauch (Vercel), Blake Scholl (Boom Supersonic), and Max Hodak (Science). Transcript: http://nav.al/industrial

00:00 Be Credible 03:18 "Yes, And" 04:31 Selfish Honesty 05:37 Charisma Is Confidence + Love 07:56 Don't Manage, Lead 11:16 Hunt Together 14:51 Feed Your (Good) Obsessions 18:57 Sell the Truth 21:07 Good Deal or No Deal 23:39 The Age of Nonlinear Returns — Transcript: http://nav.al/sell USVC is a product of AngelList, where we are founders and hold equity.

00:00 The Fully Interconnected Startup 04:14 You Don't Need the Explicit Intranet Anymore 06:55 May You Live in Interesting Times 10:40 Drones Democratize Violence 12:43 Biothreats Could Also Get Democratized 15:09 AI Interfaces Unlock Hardware 17:35 Optimism Requires Creativity -- Transcript: http://nav.al/over USVC is a product of AngelList, where we are founders and hold equity.

A Return to Coding 00:15 The Personal App Store 03:08 Vibe Coding Is a Video Game with Real-World Rewards 06:12 Pure Software Is Uninvestable 10:23 A Place for Each Model 14:09 AI Is Eager to Please 17:44 Why Math and Coding? 21:58 The Beginning of the End of Apple's Dominance 24:04 Coding Agents As Customer Service Reps 27:43 -- Transcript: http://nav.al/code Presented by AngelList: http://angellist.com/podcast We founded AngelList and have equity in the company.

If you want to learn, do 0:00 Vibe coding is the new product management 2:13 Training models is the new coding 6:49 Is traditional software engineering dead? 10:13 There is no demand for average 13:07 The hottest new programming language is English 14:12 AI is adapting to us faster than we are adapting to it 18:36 No entrepreneur is worried about AI taking their job 22:56 The goal is not to have a job 26:46 AIs are not alive 29:49 AI fails the only true test of intelligence 32:55 Early adopters of AI have an enormous edge 36:49 AI meets you exactly where you are 39:37 Always leverage the best intelligence 43:02 If you can't define it, you can't program it 44:37 The solution to AI anxiety is action 49:37 -- Transcript: http://nav.al/ai

The Best Only Want to Work With the Best 0:00 You'll Never Be Able to Hire Anybody Better Than You 3:49 Break Every Rule to Get the Best People 6:45 It Just Takes a Small Group of People to Create Something Great 10:19 Find Undiscovered Talent Before Everyone Else 14:56 Great People Have Taste in Other People 19:04 Every Great Engineer Is Also an Artist 21:24 Early Teams Look Like Cults 25:34 You Can't Make a Product that is Simple Enough 27:59 The Founder's Personality Is the Company 30:37 Good Teams Throw Away Far More Product Than They Keep 34:45 All New Information Starts as Misinformation 38:41 Geniuses Only 40:47 Practice Your Craft At the Edge of Your Capability 44:24 Curate People 49:14 — Transcript: http://nav.al/curate-people

Inspiration All the Way Down 0:00 Life is Lived in the Arena 2:40 If You Want to Learn, Do 4:51 In Most Difficult Things in Life, The Solution is Indirect 6:15 When You Truly Work for Yourself 7:30 Find Your Specific Knowledge Through Action 10:12 You Have to Enjoy It a Lot 12:06 Pause, Reflect, See How Well it Did 14:45 Blame Yourself for Everything, and Preserve Your Agency 16:23 It Is Impossible to Fool Mother Nature 21:03 The Best Authors Respect the Reader's Time 25:17 Most Books Should Be Skimmed, A Few Should Be Devoured 28:18 Good Products Are Hard to Vary 32:01 Find the Simplest Thing That Works 35:27 — Transcript http://nav.al/in-the-arena

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