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0据2022年国民抑郁症蓝皮书（www.chinadevelopmentbrief.org.cn），我国成人抑郁障碍终生患病率为6.8%，其中抑郁症为3.4%，目前我国患抑郁症人数9500万，每年大约有28万人自杀，其中40%患有抑郁症。为应对这一挑战，抗抑郁药物的使用日益普遍，特别是选择性5-羟色胺再摄取抑制剂（SSRIs），如氟西汀、帕罗西汀和舍曲林等。然而，您是否知道，这些药物可能会影响牙科种植手术的成功率？在本期播客中，我们将揭开抗抑郁药物与牙种植之间鲜为人知的联系，探讨这些常用药物如何影响骨结合过程，以及抑郁症患者在接受牙种植治疗时应注意的事项。敬请收听本期播客，了解抗抑郁药对种植手术效果的影响。
内容参考文献：
1.Silva CCG, Dos Santos MS, Monteiro JLGC, de Aguiar Soares Carneiro SC, do Egito Vasconcelos BC. Is there an association between the use of antidepressants and complications involving dental implants? A systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2021 Jan;50(1):96-103. doi: 10.1016/j.ijom.2020.03.014. Epub 2020 Jun 11. PMID: 32534847.
2.Wadhwa R, Kumar M, Talegaonkar S, Vohora D. Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms. Osteoporos Sarcopenia. 2017 Jun;3(2):75-81. doi: 10.1016/j.afos.2017.05.002. Epub 2017 Jun 9. PMID: 30775508; PMCID: PMC6372777.
3.Xiaowen Y, Zhu J, Gong M, Meng G, Tan R, Zhang Y, Chen Z. Effect of depression and the antidepressant fluoxetine on osseointegration-A pre-clinical in vivo experimental study. Clin Oral Implants Res. 2024 Oct;35(10):1355-1366. doi: 10.1111/clr.14323IF: 4.8 Q1 . Epub 2024 Jul 4. PMID: 38963167.
4.Zhou C, Fang L, Chen Y, Zhong J, Wang H, Xie P. Effect of selective serotonin reuptake inhibitors on bone mineral density: a systematic review and meta-analysis. Osteoporos Int. 2018 Jun;29(6):1243-1251. doi: 10.1007/s00198-018-4413-0. Epub 2018 Feb 12. PMID: 29435621.
5.Kang S, Han M, Park CI, Jung I, Kim EH, Boo YJ, Kang JI, Kim SJ. Use of serotonin reuptake inhibitors and risk of subsequent bone loss in a nationwide population-based cohort study. Sci Rep. 2021 Jun 29;11(1):13461. doi: 10.1038/s41598-021-92821-9. PMID: 34188108; PMCID: PMC8241982.
