你是否相信，成年人的面部骨骼仍有重塑的可能？本期节目将为大家介绍一个融合牙科、睡眠医学与发育科学的尖端领域——生物模仿口腔矫治器疗法（BOAT）。这是由斯坦福大学教授根据几十年临床经验，总结开发的一种非手术矫治器，无需手术或药物，可矫正颅面结构与气道问题，甚至改善阻塞性睡眠呼吸暂停。本次播客将介绍其如何通过极微小的力量刺激骨骼生长，审视临床证据中的气道容积变化与疗效数据，并探讨它对睡眠磨牙、面容美观乃至全身姿态的潜在影响。这是一场关于人体隐秘潜能与创新疗法的深度探索。内容均来自已发表文献，相关参考文献： 1.Williams DE, Lynch JE, Doshi V, Singh GD, Hargens AR. Bruxism and temporal bone hypermobility in patients with multiple sclerosis. Cranio. 2011 Jul;29(3):178-86. doi: 10.1179/crn.2011.026. PMID: 22586826. 2.Singh GD, Kim HN. Changes in pneumatization of the maxillary air sinuses in Korean adults following biomimetic oral appliance therapy. World J Otorhinolaryngol Head Neck Surg. 2020 Oct 19;7(2):133-138. doi: 10.1016/j.wjorl.2020.07.007. PMID: 33997723; PMCID: PMC8103532. 3.Singh GD, Heit T, Preble D, Chandrashekhar R. Changes in 3D nasal cavity volume after biomimetic oral appliance therapy in adults. Cranio. 2016 Jan;34(1):6-12. doi: 10.1179/2151090315Y.0000000001. Epub 2015 Jan 27. PMID: 25622854. 4.Singh GD. On the etiology and significance of palatal and mandibular tori. Cranio. 2010 Oct;28(4):213-5. doi: 10.1179/crn.2010.030. PMID: 21032973. 5.Singh GD, Cress SE. Craniofacial enhancement using a biomimetic oral appliance. Dent Today. 2013 Dec;32(12):92-4. PMID: 24494461. 6.Singh GD, Wendling S, Chandrashekhar R. Midfacial development in adult obstructive sleep apnea. Dent Today. 2011 Jul;30(7):124-7. PMID: 21845821. 7.Singh GD, Utama J. Effect of the DNA ApplianceTM on migraine headache: case report. Int J Orthod Milwaukee. 2013 Spring;24(1):45-9. PMID: 23729139. 8.Hwang H, Hwang C, West J, Singh GD. Changes in pediatric paranasal sinuses following biomimetic oral appliance therapy: 3 case reports. Cranio. 2022 Mar;40(2):160-165. doi: 10.1080/08869634.2019.1685217. Epub 2019 Nov 2. PMID: 31679481. 9.Singh GD, Singh M. Virtual Surgical Planning: Modeling from the Present to the Future. J Clin Med. 2021 Nov 30;10(23):5655. doi: 10.3390/jcm10235655. PMID: 34884359; PMCID: PMC8658225. 10.Singh GD. Mechanisms of upper airway remodeling following surgical interventions remain elusive. Sleep. 2021 Nov 12;44(11):zsab201. doi: 10.1093/sleep/zsab201. PMID: 34417626; PMCID: PMC8678919. 11.Singh GD, Lee S. Midfacial development and the wisdom of teeth: A case series. Clin Case Rep. 2022 Aug 24;10(8):e05133. doi: 10.1002/ccr3.5133. PMID: 36034603; PMCID: PMC9400035. 12.Singh GD, Callister JD. Effect of a maxillary appliance in an adult with obstructive sleep apnea: a case report. Cranio. 2013 Jul;31(3):171-5. doi: 10.1179/crn.2013.027. PMID: 23971157. 内容文字稿： 由于发布内容字数所限，只能将播客内容的文字稿转为图片形式上传，带来不便敬请谅解。

你知道吗？有一种“鼻窦炎”其实不是鼻子的问题，而是牙齿惹的祸！这就是牙源性上颌窦炎——一种因为牙齿感染或治疗引发的特殊鼻窦炎。 本期播客，我们将带你探索这场牙齿和鼻窦之间的“跨界战争”。为什么一颗“作怪”的牙齿可以引发单侧鼻塞、流脓甚至令人抓狂的恶臭？诊断这场“战斗”又需要哪些高科技武器？最重要的是，牙科医生和耳鼻喉科医生如何联手解决这场纠纷？ 来听听牙齿和鼻窦的故事，发现它们之间的微妙关系，以及如何打赢这场保护健康的战役！ 内容参考文献： 1.Ordinola-Zapata R, Azevedo B, Tataryn RW, Versiani MA. Maxillary Dental Anatomy and Physiology: Endodontic and Periodontal. Otolaryngol Clin North Am. 2024 Dec;57(6):927-939. doi: 10.1016/j.otc.2024.07.003IF: 1.3 Q3 . Epub 2024 Aug 30. PMID: 39214739. 2.Chiapasco M, Tommasato G. Management of Oral Surgery-Related Complications. Otolaryngol Clin North Am. 2024 Dec;57(6):1139-1155. doi: 10.1016/j.otc.2024.07.007. Epub 2024 Aug 30. PMID: 39214737. 3.Lin J, Wang C, Wang X, Chen F, Zhang W, Sun H, Yan F, Pan Y, Zhu D, Yang Q, Ge S, Sun Y, Wang K, Zhang Y, Xian M, Zheng M, Mo A, Xu X, Wang H, Zhou X, Zhang L. Expert consensus on odontogenic maxillary sinusitis multi-disciplinary treatment. Int J Oral Sci. 2024 Feb 1;16(1):11. doi: 10.1038/s41368-024-00278-z. PMID: 38302479; PMCID: PMC10834456. 4.Martu C, Martu MA, Maftei GA, Diaconu-Popa DA, Radulescu L. Odontogenic Sinusitis: From Diagnosis to Treatment Possibilities-A Narrative Review of Recent Data. Diagnostics (Basel). 2022 Jun 30;12(7):1600. doi: 10.3390/diagnostics12071600. PMID: 35885504; PMCID: PMC9319441. 5.Craig JR, Tataryn RW, Cha BY, Bhargava P, Pokorny A, Gray ST, Mattos JL, Poetker DM. Diagnosing odontogenic sinusitis of endodontic origin: A multidisciplinary literature review. Am J Otolaryngol. 2021 May-Jun;42(3):102925. doi: 10.1016/j.amjoto.2021.102925. Epub 2021 Jan 15. PMID: 33486208.

据2022年国民抑郁症蓝皮书（https://www.chinadevelopmentbrief.org.cn/news/detail/23683.html），我国成人抑郁障碍终生患病率为6.8%，其中抑郁症为3.4%，目前我国患抑郁症人数9500万，每年大约有28万人自杀，其中40%患有抑郁症。为应对这一挑战，抗抑郁药物的使用日益普遍，特别是选择性5-羟色胺再摄取抑制剂（SSRIs），如氟西汀、帕罗西汀和舍曲林等。然而，您是否知道，这些药物可能会影响牙科种植手术的成功率？在本期播客中，我们将揭开抗抑郁药物与牙种植之间鲜为人知的联系，探讨这些常用药物如何影响骨结合过程，以及抑郁症患者在接受牙种植治疗时应注意的事项。敬请收听本期播客，了解抗抑郁药对种植手术效果的影响。 内容参考文献： 1.Silva CCG, Dos Santos MS, Monteiro JLGC, de Aguiar Soares Carneiro SC, do Egito Vasconcelos BC. Is there an association between the use of antidepressants and complications involving dental implants? A systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2021 Jan;50(1):96-103. doi: 10.1016/j.ijom.2020.03.014. Epub 2020 Jun 11. PMID: 32534847. 2.Wadhwa R, Kumar M, Talegaonkar S, Vohora D. Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms. Osteoporos Sarcopenia. 2017 Jun;3(2):75-81. doi: 10.1016/j.afos.2017.05.002. Epub 2017 Jun 9. PMID: 30775508; PMCID: PMC6372777. 3.Xiaowen Y, Zhu J, Gong M, Meng G, Tan R, Zhang Y, Chen Z. Effect of depression and the antidepressant fluoxetine on osseointegration-A pre-clinical in vivo experimental study. Clin Oral Implants Res. 2024 Oct;35(10):1355-1366. doi: 10.1111/clr.14323IF: 4.8 Q1 . Epub 2024 Jul 4. PMID: 38963167. 4.Zhou C, Fang L, Chen Y, Zhong J, Wang H, Xie P. Effect of selective serotonin reuptake inhibitors on bone mineral density: a systematic review and meta-analysis. Osteoporos Int. 2018 Jun;29(6):1243-1251. doi: 10.1007/s00198-018-4413-0. Epub 2018 Feb 12. PMID: 29435621. 5.Kang S, Han M, Park CI, Jung I, Kim EH, Boo YJ, Kang JI, Kim SJ. Use of serotonin reuptake inhibitors and risk of subsequent bone loss in a nationwide population-based cohort study. Sci Rep. 2021 Jun 29;11(1):13461. doi: 10.1038/s41598-021-92821-9. PMID: 34188108; PMCID: PMC8241982.

许多人认为洗牙是多此一举，甚至是“智商税”。然而，定期洗牙是维护口腔健康的关键步骤。在本期播客中，我们将深入探讨洗牙的重要性，特别是在预防牙龈炎和牙周炎方面的作用。牙龈炎和牙周炎是口腔常见的两种炎症性疾病，主要由牙菌斑引起。 此外，我们还将分享日常口腔护理的最佳实践，帮助您全面保护牙齿健康。让我们一起了解洗牙的真正价值，打破误解，拥抱健康的笑容！ 内容参考文献： 1.Drisko CH. Nonsurgical periodontal therapy. Periodontol 2000. 2001;25:77-88. doi: 10.1034/j.1600-0757.2001.22250106.x. PMID: 11155183. 2.Worthington HV, Clarkson JE, Bryan G, Beirne PV. Routine scale and polish for periodontal health in adults. Cochrane Database Syst Rev. 2013 Nov 7;(11):CD004625. doi: 10.1002/14651858.CD004625.pub4. Update in: Cochrane Database Syst Rev. 2018 Dec 27;12:CD004625. doi: 10.1002/14651858.CD004625.pub5. PMID: 24197669. 3.Low SB, Ciancio SG. Reviewing nonsurgical periodontal therapy. J Am Dent Assoc. 1990 Oct;121(4):467-70. doi: 10.14219/jada.archive.1990.0184IF: 3.1 Q1 . PMID: 2212338. 4.Sanz I, Alonso B, Carasol M, Herrera D, Sanz M. Nonsurgical treatment of periodontitis. J Evid Based Dent Pract. 2012 Sep;12(3 Suppl):76-86. doi: 10.1016/S1532-3382(12)70019-2IF: 4.1 Q1 . PMID: 23040340.

微笑，是跨越语言的情感密码。然而，微笑的美感背后却潜藏着深刻的文化与心理密码——你的微笑，是否真的在讲述你的故事？当“中式审美”追求含蓄自然，“欧美审美”偏爱张扬奔放，微笑之美的定义变得扑朔迷离。而你，又如何在这场东西方审美对话中找到属于自己的那一份平衡？ 本期播客揭示了微笑的深层奥秘：从“形、色、心”的三要素，到中式审美与欧美审美的四维辩证法；从文化传承的自然之美，到技术赋能的个性表达，我们将解锁关于口腔美容修复的全新视角。这不仅仅是关于一口牙齿的修复，更是文化认同与个体身份的共鸣。 欢迎收听本期节目，让我们一起探索微笑之美的内在逻辑，重塑属于你的文化符号。让每一次微笑，都成为自信与故事的传递。 内容参考文献： 1.Thomas PA, Krishnamoorthi D, Mohan J, Raju R, Rajajayam S, Venkatesan S. Digital Smile Design. J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S43-S49. doi: 10.4103/jpbs.jpbs_164_22. Epub 2022 Jul 13. PMID: 36110736; PMCID: PMC9469272. 2.Hebbal MI, Helaby BS, AlHefdhi MA. Reasons for Widespread Aspiration of Esthetics Veneers "Hollywood Smile": A Survey among Five Gulf Countries. J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S923-S927. doi: 10.4103/jpbs.jpbs_680_21IF: 0.7 Q4 . Epub 2022 Jul 13. PMID: 36110658; PMCID: PMC9469267. 3.Gao Y, Niddam J, Noel W, Hersant B, Meningaud JP. Comparison of aesthetic facial criteria between Caucasian and East Asian female populations: An esthetic surgeon's perspective. Asian J Surg. 2018 Jan;41(1):4-11. doi: 10.1016/j.asjsur.2016.07.007. Epub 2016 Sep 11. PMID: 27630035. 4.Yu H, Zhao J, Sun M. Classified diagnosis and treatment scheme of oral cosmetic restoration based on aesthetic analysis (part Ⅰ): basic concept, decision tree and clinical pathway. Hua Xi Kou Qiang Yi Xue Za Zhi. 2024 Feb 1;42(1):19-27. English, Chinese. doi: 10.7518/hxkq.2024.2023212. PMID: 38475947; PMCID: PMC10965342. 5.Yu H, Zhao J, Sun M. Classified diagnosis and treatment scheme of oral cosmetic restoration based on aesthetic analysis (part Ⅱ): Chinese aesthetic connotation and analysis scheme. Hua Xi Kou Qiang Yi Xue Za Zhi. 2024 Apr 1;42(2):154-162. English, Chinese. doi: 10.7518/hxkq.2024.2023462. PMID: 38597075; PMCID: PMC11034410.

你知道吗？鲨鱼的皮肤不只是“硬朗的外衣”，它竟然和人类的牙齿有着千丝万缕的联系！这些微型的“皮肤牙齿”，是鲨鱼皮肤特有的小型硬化结构，也被译为真皮细齿（dermal denticles），不仅保护着鲨鱼免受外界伤害，还赋予它们在水中疾驰的流线型优势。而它们的发育过程和我们的牙齿居然出自同一个“祖传秘籍”——一套古老且保守的基因网络。通过研究鲨鱼的真皮齿状结构，我们有可能借此破解牙齿起源的谜题，还可能找到人类牙齿再生的秘密钥匙！今天，我们带你潜入深海，从鲨鱼的鳞片讲到人类的牙齿，再到未来牙齿再生的可能性，揭开这些惊人联系背后的科学真相。 参考文献来源： 1.Nicklin EF, Cohen KE, Cooper RL, Mitchell G, Fraser GJ. Evolution, development, and regeneration of tooth-like epithelial appendages in sharks. Dev Biol. 2024 Dec;516:221-236. doi: 10.1016/j.ydbio.2024.08.009. Epub 2024 Aug 16. PMID: 39154741. 2.Cooper RL, Nicklin EF, Rasch LJ, Fraser GJ. Teeth outside the mouth: The evolution and development of shark denticles. Evol Dev. 2023 Jan;25(1):54-72. doi: 10.1111/ede.12427. Epub 2023 Jan 3. PMID: 36594351. 3.Rasch LJ, Martin KJ, Cooper RL, Metscher BD, Underwood CJ, Fraser GJ. An ancient dental gene set governs development and continuous regeneration of teeth in sharks. Dev Biol. 2016 Jul 15;415(2):347-370. doi: 10.1016/j.ydbio.2016.01.038IF: 2.5 Q2 . Epub 2016 Feb 1. PMID: 26845577. 4.Chen D, Blom H, Sanchez S, Tafforeau P, Märss T, Ahlberg PE. The developmental relationship between teeth and dermal odontodes in the most primitive bony fish Lophosteus. Elife. 2020 Dec 15;9:e60985. doi: 10.7554/eLife.60985. PMID: 33317696; PMCID: PMC7738188. 5.Berio F, Debiais-Thibaud M. Evolutionary developmental genetics of teeth and odontodes in jawed vertebrates: a perspective from the study of elasmobranchs. J Fish Biol. 2021 Apr;98(4):906-918. doi: 10.1111/jfb.14225. Epub 2020 Jan 12. PMID: 31820456. 6.Fraser GJ, Standing A, Underwood C, Thiery AP. The Dental Lamina: An Essential Structure for Perpetual Tooth Regeneration in Sharks. Integr Comp Biol. 2020 Sep 1;60(3):644-655. doi: 10.1093/icb/icaa102IF: 2.2 Q1 . PMID: 32663287. 7.Qu Q, Sanchez S, Blom H, Tafforeau P, Ahlberg PE. Scales and tooth whorls of ancient fishes challenge distinction between external and oral 'teeth'. PLoS One. 2013 Aug 12;8(8):e71890. doi: 10.1371/journal.pone.0071890IF: 2.9 Q1 . PMID: 23951264; PMCID: PMC3741376. 8.Cooper RL, Thiery AP, Fletcher AG, Delbarre DJ, Rasch LJ, Fraser GJ. An ancient Turing-like patterning mechanism regulates skin denticle development in sharks. Sci Adv. 2018 Nov 7;4(11):eaau5484. doi: 10.1126/sciadv.aau5484. PMID: 30417097; PMCID: PMC6221541.

牙齿还能用来治失明？听起来像科幻小说，但这正是骨齿人工角膜移植术（OOKP surgery）的魔力所在！这项奇妙的手术，利用患者自己的牙齿，重建眼睛的光学系统，让那些因严重角膜疾病而陷入黑暗的人重见光明。从‘微笑露齿’到‘视界重启’，这一技术简直是医学与牙科的跨界巅峰。想知道牙齿是怎么变成‘望远镜’的吗？想了解这种神奇手术背后，那些既动人又硬核的故事吗？这一集绝对不能错过！ 内容参考文献： 1.Liu C, Paul B, Tandon R, Lee E, Fong K, Mavrikakis I, Herold J, Thorp S, Brittain P, Francis I, Ferrett C, Hull C, Lloyd A, Green D, Franklin V, Tighe B, Fukuda M, Hamada S. The osteo-odonto-keratoprosthesis (OOKP). Semin Ophthalmol. 2005 Apr-Jun;20(2):113-28. doi: 10.1080/08820530590931386. PMID: 16020351. 2.Tan A, Tan DT, Tan XW, Mehta JS. Osteo-odonto keratoprosthesis: systematic review of surgical outcomes and complication rates. Ocul Surf. 2012 Jan;10(1):15-25. doi: 10.1016/j.jtos.2012.01.003IF: 5.9 Q1 . Epub 2012 Jan 8. PMID: 22330056. 3.Liu C, Hille K, Tan D, Hicks C, Herold J. Keratoprosthesis surgery. Dev Ophthalmol. 2008;41:171-186. doi: 10.1159/000131088. PMID: 18453768. 4.Iannetti L, Liberali M, Armentano M, Alisi L, Visioli G, Mastromarino D, Brauner E, Iannetti G. Osteo-odonto-keratoprosthesis According to Strampelli Original Technique: A Retrospective Study With Up to 30 Years of Follow-up. Am J Ophthalmol. 2022 Oct;242:56-68. doi: 10.1016/j.ajo.2022.05.015IF: 4.1 Q1 . Epub 2022 May 23. PMID: 35618023. 5.Angerer MPM, Weller JM, Kruse FE, Hille K. Long-Term Outcomes of Keratoprosthesis With Biological Haptic: A Review of 25 6.Avadhanam VS, Chervenkoff JV, Zarei-Ghanavati M, Liu C. Clinical study of laminar resorption: Part 2- outcomes, review and proposal for classification. Ocul Surf. 2021 Oct;22:123-132. doi: 10.1016/j.jtos.2021.08.001IF: 5.9 Q1 . Epub 2021 Aug 4. PMID: 34363977. 7.Zarei-Ghanavati M, Liu C. Keratoprosthesis: Current Choices and Future Development. Asia Pac J Ophthalmol (Phila). 2019 Nov-Dec;8(6):429-431. doi: 10.1097/APO.0000000000000268IF: 3.7 Q1 . PMID: 31789643; PMCID: PMC6903338. 8.Enomoto A, Fukuda M, Matsunaga K, Kusaka S, Shimomura Y, Hamada S. Contribution to oral and maxillary surgery and surgical technique of osteo-odontokeratoprosthesis in Japan. Br J Oral Maxillofac Surg. 2019 Nov;57(9):861-865. doi: 10.1016/j.bjoms.2019.07.001IF: 1.7 Q2 . Epub 2019 Aug 2. PMID: 31378404. 9.de la Paz MF, Salvador-Culla B, Charoenrook V, Temprano J, Álvarez de Toledo J, Grabner G, Michael R, Barraquer RI. Osteo-odonto-, Tibial bone and Boston keratoprosthesis in clinically comparable cases of chemical injury and autoimmune disease. Ocul Surf. 2019 Jul;17(3):476-483. doi: 10.1016/j.jtos.2019.04.006IF: 5.9 Q1 . Epub 2019 Apr 12. PMID: 30986549.

你有没有想过，未来我们或许不再需要假牙？牙齿缺失，这个看似普通但却困扰无数人的问题，正迎来一场前所未有的革命。牙科医生、科学家们正在探索一种神奇的治疗方式，或许有一天，我们可以自己“长”出新牙齿！ 但这场牙齿再生的科技革命，背后究竟藏着哪些不可思议的秘密？从基因治疗到分子靶向疗法，从神秘的USAG-1抗体到RNA技术的应用，所有这些技术都在悄悄改变我们对牙齿的认知。你可能会惊讶地发现，牙齿再生不仅仅是科幻小说里的情节，它离我们越来越近。 今天的播客将带你走进这个神奇的世界，带你领略牙齿再生背后的突破性技术。准备好了吗？让我们一起打开这个充满可能性的科学宝盒，看看牙齿如何在未来的医疗中重生吧！ 内容参考文献： 1.Kiso H, Takahashi K, Saito K, Togo Y, Tsukamoto H, Huang B, Sugai M, Shimizu A, Tabata Y, Economides AN, Slavkin HC, Bessho K. Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations. PLoS One. 2014 May 9;9(5):e96938. doi: 10.1371/journal.pone.0096938IF: 2.9 Q1 . PMID: 24816837; PMCID: PMC4016158. 2.Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T. USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. Biochem Biophys Res Commun. 2004 Apr 2;316(2):490-500. doi: 10.1016/j.bbrc.2004.02.075. PMID: 15020244. 3.Saito K, Takahashi K, Asahara M, Kiso H, Togo Y, Tsukamoto H, Huang B, Sugai M, Shimizu A, Motokawa M, Slavkin HC, Bessho K. Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis. BMC Dev Biol. 2016 May 13;16:14. doi: 10.1186/s12861-016-0117-x. PMID: 27178071; PMCID: PMC4866418. 4.Togo Y, Takahashi K, Saito K, Kiso H, Tsukamoto H, Huang B, Yanagita M, Sugai M, Harada H, Komori T, Shimizu A, MacDougall M, Bessho K. Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development. PLoS One. 2016 Aug 12;11(8):e0161067. doi: 10.1371/journal.pone.0161067. PMID: 27518316; PMCID: PMC4982599. 5.Ravi V, Murashima-Suginami A, Kiso H, Tokita Y, Huang CL, Bessho K, Takagi J, Sugai M, Tabata Y, Takahashi K. Advances in tooth agenesis and tooth regeneration. Regen Ther. 2023 Feb 3;22:160-168. doi: 10.1016/j.reth.2023.01.004. PMID: 36819612; PMCID: PMC9931762. 6.Mishima S, Takahashi K, Kiso H, Murashima-Suginami A, Tokita Y, Jo JI, Uozumi R, Nambu Y, Huang B, Harada H, Komori T, Sugai M, Tabata Y, Bessho K. Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice. Sci Rep. 2021 Jul 1;11(1):13674. doi: 10.1038/s41598-021-93256-yIF: 3.8 Q1 . PMID: 34211084; PMCID: PMC8249669. 7.Murashima-Suginami A, Kiso H, Tokita Y, Mihara E, Nambu Y, Uozumi R, Tabata Y, Bessho K, Takagi J, Sugai M, Takahashi K. Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling. Sci Adv. 2021 Feb 12;7(7):eabf1798. doi: 10.1126/sciadv.abf1798. PMID: 33579703; PMCID: PMC7880588.

想让你的笑容瞬间亮起来吗？牙贴面，或许就是你实现完美微笑的秘密武器！但，牙贴面不仅仅是为了“美”，它还关系到牙齿的健康和长久保持。今天，我们要带你走进一个神奇的世界——从高强度的瓷贴面到闪亮的树脂贴面，每种材料背后都有自己的故事，挑选起来可不简单！ 你是否好奇，为什么玻璃陶瓷的牙贴面那么受欢迎？它的秘密到底是什么？或者你对微创修复感到好奇？如何在不伤害牙齿的情况下修复损伤？今天的节目中，我们将揭秘这些你可能从未听过的牙科小常识，帮助你做出最明智的选择。无论是让前牙更加迷人，还是为后牙添加力量，你的完美笑容，从这一刻开始！ 还等什么？点击收听，让我们一起揭开牙贴面背后的所有秘密，打造专属于你的璀璨笑容！ 内容参考文献： 1.Lim TW, Tan SK, Li KY, Burrow MF. SURVIVAL AND COMPLICATION RATES OF RESIN COMPOSITE LAMINATE VENEERS: A SYSTEMATIC REVIEW AND META-ANALYSIS. J Evid Based Dent Pract. 2023 Dec;23(4):101911. doi: 10.1016/j.jebdp.2023.101911IF: 4.1 Q1 . Epub 2023 Jul 17. PMID: 38035903. 2.Durán Ojeda G, Bresser RA, Wendler M, Gresnigt MMM. Ceramic partial laminate veneers in anterior teeth: A literature review. J Prosthodont Res. 2024 Apr 8;68(2):246-254. doi: 10.2186/jpr.JPR_D_23_00090IF: 3.2 Q1 . Epub 2023 Aug 31. PMID: 37648480. 3.Sirous S, Navadeh A, Ebrahimgol S, Atri F. Effect of preparation design on marginal adaptation and fracture strength of ceramic occlusal veneers: A systematic review. Clin Exp Dent Res. 2022 Dec;8(6):1391-1403. doi: 10.1002/cre2.653IF: 1.7 Q3 . Epub 2022 Sep 5. PMID: 36062841; PMCID: PMC9760166. 4.Assaf A, Azer SS, Sfeir A, Al-Haj Husain N, Özcan M. Risk Factors with Porcelain Laminate Veneers Experienced during Cementation: A Review. Materials (Basel). 2023 Jul 10;16(14):4932. doi: 10.3390/ma16144932IF: 3.1 Q1 . PMID: 37512206; PMCID: PMC10381715. 5.Chai SY, Bennani V, Aarts JM, Lyons K. Incisal preparation design for ceramic veneers: A critical review. J Am Dent Assoc. 2018 Jan;149(1):25-37. doi: 10.1016/j.adaj.2017.08.031. Erratum in: J Am Dent Assoc. 2018 Mar;149(3):173. doi: 10.1016/j.adaj.2018.01.022. PMID: 29304908. 6.Alghazzawi TF. Clinical Survival Rate and Laboratory Failure of Dental Veneers: A Narrative Literature Review. J Funct Biomater. 2024 May 16;15(5):131. doi: 10.3390/jfb15050131IF: 5.0 Q1 . PMID: 38786642IF: 5.0 Q1 ; PMCID: PMC11122289IF: 5.0 Q1 . 7.Morimoto S, Albanesi RB, Sesma N, Agra CM, Braga MM. Main Clinical Outcomes of Feldspathic Porcelain and Glass-Ceramic Laminate Veneers: A Systematic Review and Meta-Analysis of Survival and Complication Rates. Int J Prosthodont. 2016 Jan-Feb;29(1):38-49. doi: 10.11607/ijp.4315. PMID: 26757327. 8.Badami V, Satya Priya M, Vijay L, Kethineni H, Akarapu S, Agarwal S. Marginal Adaptation of Veneers: A Systematic Review. Cureus. 2022 Nov 25;14(11):e31885. doi: 10.7759/cureus.31885. PMID: 36579272; PMCID: PMC9790148. 9.Araujo E, Perdigão J. Anterior Veneer Restorations - An Evidence-based Minimal-Intervention Perspective. J Adhes Dent. 2021 Apr 7;23(2):91-110. doi: 10.3290/j.jad.b1079529IF: 2.5 Q2 . PMID: 33825424. 10.Fahl N Jr,, Ritter AV. Composite veneers: The direct-indirect technique revisited. J Esthet Restor Dent. 2021 Jan;33(1):7-19. doi: 10.1111/jerd.12696. Epub 2020 Dec 18. PMID: 33336852.

你是否知道，种植牙并不是“永久”的代名词，它也有可能被一个不太显眼的敌人困扰——种植体周围炎！这个种植牙的小麻烦，可能在不经意间悄悄滋生，影响你的“第二副牙齿”。今天，我们就来聊聊如何避免这个“潜在威胁”，以及一旦发生，它又如何影响你的微笑！ 从菌斑的“背后推手”，到先进的生物材料治疗方法，再到从翻瓣术到植骨手术的外科手段，种植体周围炎的预防和治疗都不容忽视。不管是准备种植牙的你，还是已经拥有种植体的朋友，这期节目将带你了解最新的治疗动态，并教你如何通过简单的口腔护理让种植牙远离困扰。来吧，一起守护你的种植牙免受这个小敌人的侵袭！ 内容参考文献： 1.de Avila ED, van Oirschot BA, van den Beucken JJJP. Biomaterial-based possibilities for managing peri-implantitis. J Periodontal Res. 2020 Apr;55(2):165-173. doi: 10.1111/jre.12707. Epub 2019 Oct 22. PMID: 31638267; PMCID: PMC7154698. 2.Ramanauskaite A, Cafferata EA, Begic A, Schwarz F. Surgical interventions for the treatment of peri-implantitis. Clin Implant Dent Relat Res. 2023 Aug;25(4):682-695. doi: 10.1111/cid.13162IF: 3.7 Q1 . Epub 2022 Nov 23. PMID: 36419243. 3.Ting M, Suzuki JB. Peri-Implantitis. Dent J (Basel). 2024 Aug 9;12(8):251. doi: 10.3390/dj12080251IF: 2.5 Q2 . PMID: 39195095; PMCID: PMC11352821. 4.Fu JH, Wang HL. Breaking the wave of peri-implantitis. Periodontol 2000. 2020 Oct;84(1):145-160. doi: 10.1111/prd.12335IF: 17.5 Q1 . PMID: 32844418. 5.Schwarz F, Jepsen S, Obreja K, Galarraga-Vinueza ME, Ramanauskaite A. Surgical therapy of peri-implantitis. Periodontol 2000. 2022 Feb;88(1):145-181. doi: 10.1111/prd.12417. PMID: 35103328. 6.Schwarz F, Derks J, Monje A, Wang HL. Peri-implantitis. J Periodontol. 2018 Jun;89 Suppl 1:S267-S290. doi: 10.1002/JPER.16-0350IF: 4.2 Q1 . PMID: 29926957. 7.Darby I. Risk factors for periodontitis & peri-implantitis. Periodontol 2000. 2022 Oct;90(1):9-12. doi: 10.1111/prd.12447IF: 17.5 Q1 . Epub 2022 Aug 1. PMID: 35913624; PMCID: PMC9804916.

牙齿受伤，别慌！今天的播客就来聊聊，当我们的牙齿遇到“意外时刻”，该怎么处理。无论是孩子的乳牙摔掉了，还是大人不小心磕坏了恒牙，别担心，我们有妙招！ 在这一期节目里，我们会分享乳牙和恒牙受伤时的处理秘诀。你知道吗？乳牙和恒牙的“急救”方法可是完全不同的！我们会告诉你，什么时候应该紧急处理，什么时候可以静观其变，如何在伤害最小的情况下保护好发育中的恒牙。 如果你的孩子牙齿受伤了，或者你自己刚刚在运动中磕掉了牙，赶紧来听听我们给你准备的实用tips！从处理创伤到预防后遗症，咱们一步步带你搞定所有牙外伤问题。 内容参考文献： 1.Tewari N, Bansal K, Mathur VP. Dental Trauma in Children: A Quick Overview on Management. Indian J Pediatr. 2019 Nov;86(11):1043-1047. doi: 10.1007/s12098-019-02984-7IF: 2.1 Q2 . Epub 2019 Jun 13. PMID: 31197645. 2.Day PF, Flores MT, O'Connell AC, Abbott PV, Tsilingaridis G, Fouad AF, Cohenca N, Lauridsen E, Bourguignon C, Hicks L, Andreasen JO, Cehreli ZC, Harlamb S, Kahler B, Oginni A, Semper M, Levin L. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 3. Injuries in the primary dentition. Dent Traumatol. 2020 Aug;36(4):343-359. doi: 10.1111/edt.12576. PMID: 32458553. 3.Bourguignon C, Cohenca N, Lauridsen E, Flores MT, O'Connell AC, Day PF, Tsilingaridis G, Abbott PV, Fouad AF, Hicks L, Andreasen JO, Cehreli ZC, Harlamb S, Kahler B, Oginni A, Semper M, Levin L. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 1. Fractures and luxations. Dent Traumatol. 2020 Aug;36(4):314-330. doi: 10.1111/edt.12578. Epub 2020 Jul 17. PMID: 32475015. 4.Levin L, Day PF, Hicks L, O'Connell A, Fouad AF, Bourguignon C, Abbott PV. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: General introduction. Dent Traumatol. 2020 Aug;36(4):309-313. doi: 10.1111/edt.12574IF: 2.3 Q2 . Epub 2020 Jun 22. PMID: 32472740. 5.Fouad AF, Abbott PV, Tsilingaridis G, Cohenca N, Lauridsen E, Bourguignon C, O'Connell A, Flores MT, Day PF, Hicks L, Andreasen JO, Cehreli ZC, Harlamb S, Kahler B, Oginni A, Semper M, Levin L. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth. Dent Traumatol. 2020 Aug;36(4):331-342. doi: 10.1111/edt.12573IF: 2.3 Q2 . Epub 2020 Jun 13. PMID: 32460393.

你有过在夜晚猛然惊醒，气喘吁吁的感觉吗？或者半夜总是被鼾声吵醒，睡得不够安稳？这可能是“阻塞性睡眠呼吸暂停综合征”（OSAS）在作怪！在这期播客中，我们将带你深入探讨这个“悄悄在黑暗中作乱”的睡眠敌人，从令人惊讶的症状到那些不为人知的复杂机制，揭秘它如何悄悄影响你的健康。你能想象吗？它不仅仅影响你的夜间休息，还可能悄悄侵袭你的心脏、大脑，甚至你的代谢系统！一起跟随我们的步伐，探索如何打破这场夜间的呼吸迷雾，找到应对的智慧和解决方案！ 内容参考文献： 1.Lv R, Liu X, Zhang Y, Dong N, Wang X, He Y, Yue H, Yin Q. Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome. Signal Transduct Target Ther. 2023 May 25;8(1):218. doi: 10.1038/s41392-023-01496-3. PMID: 37230968; PMCID: PMC10211313. 2.Lévy P, Kohler M, McNicholas WT, Barbé F, McEvoy RD, Somers VK, Lavie L, Pépin JL. Obstructive sleep apnoea syndrome. Nat Rev Dis Primers. 2015 Jun 25;1:15015. doi: 10.1038/nrdp.2015.15IF: 76.9 Q1 . PMID: 27188535. 3.Lee JJ, Sundar KM. Evaluation and Management of Adults with Obstructive Sleep Apnea Syndrome. Lung. 2021 Apr;199(2):87-101. doi: 10.1007/s00408-021-00426-wIF: 4.6 Q1 . Epub 2021 Mar 13. PMID: 33713177. 4.Bitners AC, Arens R. Evaluation and Management of Children with Obstructive Sleep Apnea Syndrome. Lung. 2020 Apr;198(2):257-270. doi: 10.1007/s00408-020-00342-5IF: 4.6 Q1 . Epub 2020 Mar 12. PMID: 32166426; PMCID: PMC7171982.

如果你曾经在说话或咀嚼时感到耳前区疼痛，或者大张嘴时，关节发出奇怪的“咔嚓”声，那么你可能正在经历一种叫做颞下颌关节紊乱症（TMD）（不是骂人)的困扰。 TMD不仅仅是简单的“下巴疼”，它可能会引发从头痛、耳鸣到面部肌肉紧张等多种症状，严重时甚至影响我们的日常生活质量。根据研究，约有10%到15%的成年人都曾受到TMD的困扰，其中女性的发病率是男性的两倍。 在这一期的播客中，我们将介绍颞下颌关节紊乱症的症状、原因和诊断方法。我们还将分享如何通过保守治疗和自我护理来缓解这些令人不适的症状，以及如何在医生的帮助下有效地管理TMD。 不仅如此，我们还会从“磨牙症”这一诱因入手，探讨如何避免不良习惯的加剧作用，以及如何通过简单的生活习惯调整来减轻症状。 如果你是TMD患者，或者你身边有正在遭受TMD困扰的亲朋好友，这期节目绝对不容错过！让我们一起揭开颞下颌关节紊乱症的真面目，了解如何更好地护理我们的颞下颌关节健康！ 内容参考文献： 1.Gauer RL, Semidey MJ. Diagnosis and treatment of temporomandibular disorders. Am Fam Physician. 2015 Mar 15;91(6):378-86. PMID: 25822556. 2.Ferneini EM. Temporomandibular Joint Disorders (TMD). J Oral Maxillofac Surg. 2021 Oct;79(10):2171-2172. doi: 10.1016/j.joms.2021.07.008. PMID: 34620421. 3.Murphy MK, MacBarb RF, Wong ME, Athanasiou KA. Temporomandibular disorders: a review of etiology, clinical management, and tissue engineering strategies. Int J Oral Maxillofac Implants. 2013 Nov-Dec;28(6):e393-414. doi: 10.11607/jomi.te20IF: 1.7 Q3 . PMID: 24278954; PMCID: PMC4349514. 4.Matheson EM, Fermo JD, Blackwelder RS. Temporomandibular Disorders: Rapid Evidence Review. Am Fam Physician. 2023 Jan;107(1):52-58. PMID: 36689971. 5.Scrivani SJ, Keith DA, Kaban LB. Temporomandibular disorders. N Engl J Med. 2008 Dec 18;359(25):2693-705. doi: 10.1056/NEJMra0802472. PMID: 19092154.

你是否曾在早晨醒来，突然感觉牙齿酸痛，或是下巴疼得像被锤过一样？又或者，你是否曾在深夜被“咯吱咯吱”的磨牙声惊醒？不管是睡觉时的磨牙，还是清醒时紧咬牙关，磨牙症不仅让患者饱受困扰，还深深影响着他们的“枕边人”。今天，我们就来聊聊磨牙症的那些事儿！ 磨牙症究竟是压力引发的无声“战争”，还是在睡梦中的神秘习惯？这一期，我们将带你深入探讨磨牙症的背后，揭开它的生理、心理以及日常生活中的各种因素。更重要的是，磨牙症不仅仅是一个与患者自己相关的话题，它其实是一个关于“我们”的故事。特别是那些睡在磨牙症患者身边的人，如果你曾被夜间的磨牙声惊醒，或是担心伴侣的牙齿健康，这期节目你绝对不容错过！ 内容参考文献： 1.Matusz K, Maciejewska-Szaniec Z, Gredes T, Pobudek-Radzikowska M, Glapiński M, Górna N, Przystańska A. Common therapeutic approaches in sleep and awake bruxism - an overview. Neurol Neurochir Pol. 2022;56(6):455-463. doi: 10.5603/PJNNS.a2022.0073IF: 2.9 Q2 . Epub 2022 Nov 29. PMID: 36444852. 2.Aguilera SB, Brown L, Perico VA. Aesthetic Treatment of Bruxism. J Clin Aesthet Dermatol. 2017 May;10(5):49-55. Epub 2017 May 1. PMID: 28670358; PMCID: PMC5479477. 3.Goldstein G, DeSantis L, Goodacre C. Bruxism: Best Evidence Consensus Statement. J Prosthodont. 2021 Apr;30(S1):91-101. doi: 10.1111/jopr.13308IF: 3.4 Q1 . PMID: 33331675. 4.Lavigne GJ, Khoury S, Abe S, Yamaguchi T, Raphael K. Bruxism physiology and pathology: an overview for clinicians. J Oral Rehabil. 2008 Jul;35(7):476-94. doi: 10.1111/j.1365-2842.2008.01881.xIF: 3.1 Q1 . PMID: 18557915. 5.Manfredini D, Ahlberg J, Aarab G, Bender S, Bracci A, Cistulli PA, Conti PC, De Leeuw R, Durham J, Emodi-Perlman A, Ettlin D, Gallo LM, Häggman-Henrikson B, Hublin C, Kato T, Klasser G, Koutris M, Lavigne GJ, Paesani D, Peroz I, Svensson P, Wetselaar P, Lobbezoo F. Standardised Tool for the Assessment of Bruxism. J Oral Rehabil. 2024 Jan;51(1):29-58. doi: 10.1111/joor.13411IF: 3.1 Q1 . Epub 2023 Feb 10. PMID: 36597658.

你有没有遇到过咬东西时突然冒出来的尖锐疼痛？或者牙齿看似完好，却在某些瞬间让你感到不适？这背后可能藏着“牙隐裂”！但别急，今天的播客就来帮你解开这个谜团！我们将带你探索牙隐裂的奥秘，如何发现它，为什么它会悄悄地悄然“裂开”，以及我们能做些什么来挽救它。你知道吗，有时候一颗牙齿的裂纹，可能会悄悄影响到整个口腔健康！想了解更多？那就跟我们一起揭秘这些“裂裂不休”的牙齿吧！ 内容参考文献： 1.Li F, Diao Y, Wang J, Hou X, Qiao S, Kong J, Sun Y, Lee ES, Jiang HB. Review of Cracked Tooth Syndrome: Etiology, Diagnosis, Management, and Prevention. Pain Res Manag. 2021 Dec 15;2021:3788660. doi: 10.1155/2021/3788660IF: 2.5 Q2 . PMID: 34956432; PMCID: PMC8694987. 2.Yap RC, Alghanem M, Martin N. A narrative review of cracks in teeth: Aetiology, microstructure and diagnostic challenges. J Dent. 2023 Nov;138:104683. doi: 10.1016/j.jdent.2023.104683. Epub 2023 Sep 13. PMID: 37713950. 3.Zidane B. Recent Advances in the Diagnosis of Enamel Cracks: A Narrative Review. Diagnostics (Basel). 2022 Aug 22;12(8):2027. doi: 10.3390/diagnostics12082027. PMID: 36010379; PMCID: PMC9407313. 4.Zhang S, Xu Y, Ma Y, Zhao W, Jin X, Fu B. The treatment outcomes of cracked teeth: A systematic review and meta-analysis. J Dent. 2024 Mar;142:104843. doi: 10.1016/j.jdent.2024.104843. Epub 2024 Jan 24. PMID: 38272437. 5.Kakka A, Gavriil D, Whitworth J. Treatment of cracked teeth: A comprehensive narrative review. Clin Exp Dent Res. 2022 Oct;8(5):1218-1248. doi: 10.1002/cre2.617IF: 1.7 Q3 . Epub 2022 Jul 9. PMID: 35809233; PMCID: PMC9562569. 6.Yu M, Li J, Liu S, Xie Z, Liu J, Liu Y. Diagnosis of cracked tooth: Clinical status and research progress. Jpn Dent Sci Rev. 2022 Nov;58:357-364. doi: 10.1016/j.jdsr.2022.11.002IF: 5.7 Q1 . Epub 2022 Nov 17. PMID: 36425316; PMCID: PMC9678967.