全球约2.8亿人受心脏瓣膜问题困扰,药物无效只能手术,现有替换方案有缺陷。科学家用干细胞构建出带功能性瓣膜的三维心脏类器官,为研究瓣膜发育、病变及药物测试提供新模型,有望推动个性化治疗和再生瓣膜研发。
参考文献:
He Y et al. (Li G, 通讯作者). Human iPSC-derived heart valve-like assembloids model valve development and disease pathology. Cell Stem Cell. 2026-08-11. DOI: 10.1016/j.stem.2026.07.011. www.cell.com(26)00271-7
Voges HK et al. Human heart valve-like tissues from pluripotent stem cells with enhanced maturation recapitulate inflammatory valve disease. Cell Stem Cell. 2026-08-11. DOI: 10.1016/j.stem.2026.07.010
University of Pittsburgh. Heart assembloids give researchers a new way to study heart valve disorders. 2026-08-11. www.pittwire.pitt.edu
科技日报. 类器官上首次培育出功能性心脏瓣膜,能模拟发育和病变过程. 2026-08-12. www.stdaily.com
Bioengineer.org. Heart assembloids offer new insights into heart valve disorders. 2026-08-11. bioengineer.org

